mosaicmpi.integration.Integration.compute_pairwise_thresholds

Integration.compute_pairwise_thresholds(negative_corr_quantile: float = 0.95) → None

Compute thresholds for each dataset and dataset pair based on the correlation distribution of programs. This dynamic thresholding enables integration and balances the influence of each dataset in the network.

Parameters:

negative_corr_quantile (float, optional) – Threshold for network-based integration, between 0 and 1, with 1 resulting in fewer edges in the network. Defaults to 0.95